Dexedrine (Dextroamphetamine)


Elimination half-life: 9–11 hours; pH-dependent: 7–34 hours
Duration of action: IR dosing: 3–6 hours; XR dosing: 8–12 hours
Onset of action: IR dosing: 0.5–1.5 hours; XR dosing: 1.5–2 hours
Metabolism: CYP2D6, DBH, FMO3
Other names: D-Amphetamine
Addiction liability: High
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Dexedrine (Dextroamphetamine)

What is Dexedrine?

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Dextroamphetamine is a central nervous system stimulant and an amphetamine enantiomer that is prescribed for the treatment of attention deficit hyperactivity disorder and narcolepsy. It is also used as an athletic performance and cognitive enhancer, and recreationally as an aphrodisiac and euphoriant.
Elimination half-life: 9–11 hours; pH-dependent: 7–34 hours
Duration of action: IR dosing: 3–6 hours; XR dosing: 8–12 hours
Onset of action: IR dosing: 0.5–1.5 hours; XR dosing: 1.5–2 hours
Metabolism: CYP2D6, DBH, FMO3
Other names: D-Amphetamine
Addiction liability: High


DEXEDRINE (dextroamphetamine sulfate) is the dextro isomer of the compound d,l-amphetamine sulfate, a
sympathomimetic amine of the amphetamine group. Chemically, dextroamphetamine is
d-alpha-methylphenethylamine and is present in all forms of DEXEDRINE as the neutral sulfate.
Structural formula:
SPANSULE capsules: Each SPANSULE sustained-release capsule is so prepared that an initial dose is

DEXEDRINE is indicated as an integral part of a total treatment program for ADHD that may include other measures (psychological, educational, social) for patients with this syndrome. Drug treatment may not be indicated for all patients with this syndrome. Stimulants are not intended for use in patients who exhibit symptoms secondary to environmental factors and/or other primary psychiatric disorders, including psychosis. Appropriate educational placement is essential and psychosocial intervention is often helpful. When remedial measures alone are insufficient, the decision to prescribe stimulant medication will depend upon the physician’s assessment of the chronicity and severity of the patient’s symptoms.



Amphetamines are noncatecholamine, sympathomimetic amines with CNS stimulant activity. Peripheral actions include elevations of systolic and diastolic blood pressures and weak bronchodilator and respiratory stimulant action. There is neither specific evidence that clearly establishes the mechanism whereby amphetamines produce mental and behavioral effects in children, nor conclusive evidence regarding how these effects relate to the condition of the central nervous system. DEXEDRINE SPANSULE Capsules are formulated to release the active drug substance in vivo in a more gradual fashion than the standard formulation, as demonstrated by blood levels. The formulation has not been shown superior in effectiveness over the same dosage of the standard, noncontrolled-release formulations given in divided doses.

Are there any major differences between Dexedrine and other stimulants used to treat ADHD?

There are a lot of similarities between central nervous systems stimulants used to treat ADHD. They are all habit-forming and classified as Schedule II controlled substances.  Therefore, if you have a history of substance use problems, you should talk to your doctor about this before taking either medication. The major distinction is the different release formats of the medications. Some medications come in the instant release, whereas others come in extended-release. Talk to your doctor about other medical conditions you have and they can help you make an informed choice.

Can children take Dexedrine?

Children over the age of 6 may be prescribed Dexedrine for ADHD. They should take the medication in the exact amount prescribed by their doctor. It’s also important to tell your child’s doctor about other medication complications or past substance use history and to monitor their growth while on the medication.

Are there potential interaction issues for people taking Dexedrine and any other drugs?

Do not take Dexedrine if you have taken an MAO inhibitor in the past two weeks, as a dangerous interaction effect could occur. There are also hundreds of drugs that are known to interact with Dexedrine in major, moderate, or mild ways, so let your doctor know what other medications you are taking before you begin taking the medication.

Are there any other medical conditions that would make someone ineligible for Dexedrine therapy?

You should not take Dexedrine if you have heart disease or other heart problems, hypertension, glaucoma, extreme agitation, or hyperthyroidism. If you have a history of substance use problems or mental illness, talk to your doctor about the risks.

What is the typical dose that would be prescribed to someone taking Dexedrine?

For patients ages 6 and over, the starting dosage is typically 5 mg once or twice a day. The maximum recommended daily dosage is 40 mg.

How long does Dexedrine work?

Dexedrine Spansule capsules are the extended-release form and are only taken once a day. Dexedrine tablets can last from 4-6 hours and are taken 2-3 times per day.

What do I do if I miss a dose?

Take the dose of Dexedrine when you remember, but skip the missed dose if it is already or almost evening, as it can cause problems with sleeping. You should never take extra doses of the medication to make up for missed doses.

 What are Dexedrine’s common side effects?

Common side effects of Dexedrine can include:

  • headache
  • upset stomach
  • decreased appetite
  • insomnia
  • dizziness
  • weight loss
  • tremors
  • dry mouth.

Children who take Dexedrine sometimes may experience a temporary slowing in their rate of growth. If you experience major side effects, report them to your doctor immediately and stop using the medication. Major side effects can include seizures, blurred vision, hypertension, and stroke. You can report side effects to the FDA at 1-800-FDA or online.

Are there any possible psychiatric side effects that come from taking Dexedrine?

Dexedrine can also cause or worsen symptoms of mental illness, including psychosis and mania, and it may increase aggressive behavior among children or teens.

Is it safe for a woman who is pregnant, about to become pregnant, or nursing to take Dexedrine?

There have been no controlled human pregnancy studies on the effects of Dexedrine, but there is a heightened risk of premature birth and lower weight at birth for babies of mothers who are dependent on amphetamines. Amphetamines can be transferred via breast milk in small amounts and harm a baby. Therefore, talk to your doctor if you are pregnant, planning to become pregnant, or are nursing before you take Dexedrine.

Can symptoms occur if Dexedrine is discontinued?

Withdrawal symptoms of Dexedrine can also include depressed mood, extreme fatigue, irritability, hunger, seizures, aggressive outbursts, and confusion. Symptoms are sometimes experienced within a day of discontinuing the medication. Maintain contact with your doctor and seek medical attention if necessary when discontinuing the drug.

What should I do if I overdose on Dexedrine?

An overdose of Dexedrine could be fatal, so seek immediate help or call the Poison Help Line at 1-800-222-1222 if you overdose. Overdose symptoms can include nausea, vomiting, headache, rapid breathing or heart rate, high blood pressure, seizures, and severe mood swings.

Is Dexedrine habit-forming?.

Buy Dexedrine (Dextroamphetamine) online now uk

Dexedrine is a Schedule II controlled substance and can be habit-forming, as users may develop a tolerance to the drug over time. Make sure that you keep track of the medication and never take more than prescribed. It is illegal to give or sell the medication to others. Talk to your doctor if you have a past history of substance dependence before you begin taking the medication.

Sixty tablets of 5 mg of dextroamphetamine range from $30 to $100.

Are there any disadvantages to Dexedrine?

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The biggest disadvantage of Dexedrine is that it is very habit-forming. The drug is frequently abused as a “study drug” for school performance among college students, and it is also abused for weight loss. If you have a history of abusing substances or have a history of substance use in your family, then the drug may not be right for you. Also, the common side effects may outweigh the benefits.

DISCLAIMER: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other healthcare provider.  This article mentions drugs that were FDA-approved and available at the time of publication and may not include all possible drug interactions or all FDA warnings or alerts. The author of this page explicitly does not endorse this drug or any specific treatment method. If you have health questions or concerns about interactions, please check with your physician or go to the FDA site for a comprehensive list of warnings.


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